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KMID : 0357220070190010057
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Journal of Korean Society Physical Therapy
2007 Volume.19 No. 1 p.57 ~ p.66
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Therapeutic Effects of Achyrantes Radix and Electroacupuncture of Zusanli acupoint(ST36) on Type II Collagen-Induced Arthritis
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Lee Jae-Choon
Oh Myung-Hwa
Nam Ki-Won
Kim Young-Eok
Yoo Young-Dae
Chang Mee-Kyung
Kim Gye-Yeop
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Abstract
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Purpose: We investigated the effects of the combined therapy in rats with rheumatoid arthritis induced by type II collagen for 28 days, which consisted of the oral administration of the AR and EA applied to zusanli acupoint(ST36).
Methods: Normal group was oral administered with 0.9% NaCl $0.5\;m{\ell}/day$ to normal rats. Control group was oral administered with 0.9% NaCl $0.5\;m{\ell}/day$ to arthritic rats. Group I was oral administered with AR 500 mg/kg $0.5\;m{\ell}/day$ to arthritic rats. Group II was given 2 Hz EA of ST36 in the test group for 30 min/day to arthritic rats. Group III was oral administered with AR 500 mg/kg $0.5\;m{\ell}/day$ and 2 Hz EA of ST36 in the test group for 30 min/day to arthritic rats. We Observed effect of the histopathological changes by H&E stain of liver, kidney, knee joint and ELSIA of cytokines($TNF-{\alpha}$).
Results: 1. The vacuolization of liver tissue was decreased in group I, II, III comparing with control group. 2. The glomerular sclerosis of kidney tissue was decreased in group I, II, III comparing with control group. 3. The erosion of arthritic site of knee joint tissue was decreased group I, II, III comparing with control group. In particular group III was the most effective comparing with group I, II on the histopathological view. 4. In the ELSIA test of $TNF-{\alpha}$ concentration, Control group significantly increased in the concentration more than group I, II, III. The rate of increase in concentration slowed down in group III more than group I, II(p<0.05).
Conclusions: It is concluded that 500 mg/kg of AR extracts and EA have clear therapeutic effect on the rheumatoid arthritis.
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KEYWORD
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Rheumatoid arthritis, Achyranthes Radix, Electroacupuncture, $TNF-{\alpha}$
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